{"id":3950,"date":"2022-06-20T00:54:44","date_gmt":"2022-06-20T00:54:44","guid":{"rendered":"https:\/\/math.compbio.ru\/en\/\/?p=3950"},"modified":"2022-07-11T07:37:04","modified_gmt":"2022-07-11T07:37:04","slug":"development-gene-networks","status":"publish","type":"post","link":"http:\/\/127.0.0.1:1933\/en\/development-gene-networks\/","title":{"rendered":"Development &#038; gene networks"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l4m0ylfu-1efa3b8bf942bb6c66db3c80f4f42a95\">\n.avia-section.av-l4m0ylfu-1efa3b8bf942bb6c66db3c80f4f42a95{\nbackground-repeat:no-repeat;\nbackground-image:url(http:\/\/127.0.0.1:1933\/en\/wp-content\/uploads\/2022\/06\/shutterstock_1925004881-1030x561.jpeg);\nbackground-position:50% 50%;\nbackground-attachment:fixed;\n}\n.avia-section.av-l4m0ylfu-1efa3b8bf942bb6c66db3c80f4f42a95 .av-section-color-overlay{\nopacity:0.6;\nbackground-color:#000000;\n}\n<\/style>\n<div id='av_section_1'  class='avia-section av-l4m0ylfu-1efa3b8bf942bb6c66db3c80f4f42a95 main_color avia-section-huge avia-no-shadow  avia-builder-el-0  el_before_av_textblock  avia-builder-el-first  avia-full-stretch avia-bg-style-fixed av-section-color-overlay-active container_wrap fullsize'  data-section-bg-repeat='stretch'><div class=\"av-section-color-overlay-wrap\"><div class=\"av-section-color-overlay\"><\/div><div class='container av-section-cont-open' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-3950'><div class='entry-content-wrapper clearfix'>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-l4m0y8a1-4af25844dd9a0526156b3fa6eecff3cb\">\n#top .av-special-heading.av-l4m0y8a1-4af25844dd9a0526156b3fa6eecff3cb{\npadding-bottom:0px;\ncolor:#ffffff;\nfont-size:40px;\n}\nbody .av-special-heading.av-l4m0y8a1-4af25844dd9a0526156b3fa6eecff3cb .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n#top #wrap_all .av-special-heading.av-l4m0y8a1-4af25844dd9a0526156b3fa6eecff3cb .av-special-heading-tag{\nfont-size:40px;\n}\n.av-special-heading.av-l4m0y8a1-4af25844dd9a0526156b3fa6eecff3cb .special-heading-inner-border{\nborder-color:#ffffff;\n}\n.av-special-heading.av-l4m0y8a1-4af25844dd9a0526156b3fa6eecff3cb .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-l4m0y8a1-4af25844dd9a0526156b3fa6eecff3cb av-special-heading-h1 custom-color-heading blockquote modern-quote modern-centered  avia-builder-el-1  avia-builder-el-no-sibling  av-inherit-size'><h1 class='av-special-heading-tag'  itemprop=\"headline\"  >Development <span class='special_amp'>&amp;<\/span> gene networks<\/h1><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><\/div><div id='after_section_1'  class='main_color av_default_container_wrap container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-3950'><div class='entry-content-wrapper clearfix'><section  class='av_textblock_section av-l4m0yuz8-24bf1fcc2627a19b77ded7aff313d821'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><p>In the course of early development, cells acquire their specificity through the action the gene networks driving cell fate determination and cell differentiation.<\/p>\n<p>These systems are intrinsically complex, both fragile and resilient at the same time. Mathematical modelling of gene networks is an essential facet of computational biology allowing for deep understanding of the biological system in question, as well as for nonintuitive insights into how such systems can be manipulated. Building predictive models is especially challenging as stochasticity of gene expression presents significant challenges.<\/p>\n<p>For years now fruit fly, Drosophila melanogaster, has been a model organism to study transcription and gene regulatory networks. We use a combination of experimental approaches and stochastic modelling to characterise and investigate transcriptional regulatory networks during early embryo development and in the complex eye of the fruit fly.<\/p>\n<\/div><\/section><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":3899,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-3950","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research"],"_links":{"self":[{"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/posts\/3950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/comments?post=3950"}],"version-history":[{"count":4,"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/posts\/3950\/revisions"}],"predecessor-version":[{"id":4115,"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/posts\/3950\/revisions\/4115"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/media\/3899"}],"wp:attachment":[{"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/media?parent=3950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/categories?post=3950"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/127.0.0.1:1933\/en\/wp-json\/wp\/v2\/tags?post=3950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}